It may be the dose prescribed…the type of epilepsy you have…even something as simple as your age or weight. But research shows that, over time, the effectiveness of your anti-epilepsy drug may decline.
Almost all first, second and third-generation epilepsy drugs lose their efficacy after prolonged treatment.
Perhaps it’s because your metabolism builds up a tolerance to the drug. And ramping up the dosage can work.
Or it may be a functional tolerance where your brain receptors have become resistant to the drug. In that case, a change in medications may help. But whatever the cause, you’re not alone…
Patients showing tolerance to traditional drugs
A critical review by Dr. Wolfgang Loscher and Dr. Dieter Schmidt shows that repeated administration of anti-epileptic drug (AED) therapy has diminishing results in preventing seizures in epileptic patients.
In clinical trials, the number of patients remaining seizure-free declines over time with prolonged treatment.
This review explores…
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